Project Overview
Shenyang 3SBio Inc., a high-tech enterprise specializing in the R&D, production, and sales of biological medicines, required a advanced multi-temperature cold storage logistics facility. This project, located in the Economic and Technological Development Zone of Shenyang, Liaoning Province, was designed and constructed by Haoshuang Refrigeration to meet stringent GMP/GSP standards. The 3000m² warehouse features multiple temperature zones:
- 2-8°C refrigerated storage
- 15-20°C / 20-25°C constant temperature storage
- -25°C frozen storage
The facility also maintains humidity levels between 35% and 75%, with fully automated temperature and humidity control.
Key Requirements
- Multi-Temperature Zones: Precise control across冷藏, constant temperature, and frozen storage.
- Regulatory Compliance: Meet GMP/GSP certification standards.
- Centralized Management: Real-time monitoring and control with alarm systems.
- Energy Efficiency: Optimized equipment selection to reduce operational costs.
- Backup Systems: Redundant power and refrigeration units to ensure uninterrupted operation.
Technical Solution
1. Refrigeration System
- Compressors: German-made Bitzer semi-hermetic piston parallel units for high stability and efficiency.
- Evaporators: Customized long-distance air supply evaporators from Haoshuang for rapid cooling, even temperature distribution, and efficient defrosting.
- Refrigerant: Environmentally friendly R404a.
2. Insulation Structure
- Refrigerated Storage (2-8°C): 120mm polyurethane double-sided color steel panels.
- Constant Temperature Storage (15-25°C): 100mm polyurethane double-sided color steel panels.
- Frozen Storage (-25°C): 150mm polyurethane double-sided color steel panels.
Advantages: Moisture-proof, fire-resistant (B1 grade), and excellent thermal insulation to reduce energy consumption.
3. Control & Monitoring
- Fully automated imported temperature control system with real-time monitoring, data logging, and mobile alerts.
- PLC-based programmable logic control for customized temperature and humidity adjustments.
- Backup generator and dual-circuit power supply to ensure 24/7 operation.
4. Validation & Compliance
- The facility passed a one-month validation period and performance challenge tests, fully complying with GMP/GSP standards.
About Shenyang 3SBio
Established in 1993, Shenyang 3SBio Inc. is a leading bio-pharmaceutical company specializing in recombinant protein-based drugs. Its flagship products include recombinant human erythropoietin and recombinant human thrombopoietin (“TPIAO”), addressing clinical needs in nephrology, oncology, and inflammatory diseases.
Construction & Completion Photos

Shenyang 3SBio Inc office reception desk

Pharmaceutical cold storage is put into use

Pharmaceutical cold storage is put into use

Real scene of the computer room

Pharmaceutical cold storage compartment aisle